Entry #10: Gut and Feelings
Have you ever found yourself lying in bed, stress-eating while doom-scrolling? Have you felt yourself with no energy to do anything, let alone get yourself in order? Have you ever wondered why your brain feels like it's running on an old version of Windows? Could the answer to your mental funk be hiding... in your gut?
Yes. Turns out your stomach isn't just for digesting food and holding butterflies after your crush gave you that look. It's actually got a pretty active side gig as the gut is the "second brain." Scientists have coined this term, and to be honest, sometimes it seems like the real brain isn't in charge anymore. Your gut could actually help improve your mental health, sounds insane, doesn't it? Antidepressants have been the go-to treatment for anxiety and depression, and they've helped a lot of people. But more recently, studies are pointing to something surprising: probiotics and prebiotics-compounds that support a healthy gut microbiome-might be just as effective in some cases.
Bacteria Party
VIP: Probiotics and Prebiotics
Why it Matters
References
Cryan, J. F., O’Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., ... & Dinan, T. G. (2019). The microbiota-gut-brain axis. Physiological Reviews, 99(4), 1877–2013. https://doi.org/10.1152/physrev.00018.2018
Gershon, M. D., & Tack, J. (2007). The serotonin signaling system: From basic understanding to drug development for functional GI disorders. Gastroenterology, 132(1), 397–414. https://doi.org/10.1053/j.gastro.2006.11.002
Mayer, E. A., Knight, R., Mazmanian, S. K., Cryan, J. F., & Tillisch, K. (2014). Gut microbes and the brain: Paradigm shift in neuroscience. Journal of Neuroscience, 34(46), 15490–15496. https://doi.org/10.1523/JNEUROSCI.3299-14.2014
Ng, Q. X., Peters, C., Ho, C. Y. X., Lim, D. Y., & Yeo, W. S. (2018). A meta-analysis of the use of probiotics to alleviate depressive symptoms. Journal of Affective Disorders, 228, 13–19. https://doi.org/10.1016/j.jad.2017.11.063
Reis, D. J., Ilardi, S. S., & Punt, S. E. W. (2018). The anxiolytic effect of probiotics: A systematic review and meta-analysis of the clinical and preclinical literature. PLoS ONE, 13(6), e0199041. https://doi.org/10.1371/journal.pone.0199041
Schmidt, K., Cowen, P. J., Harmer, C. J., Tzortzis, G., Errington, S., & Burnet, P. W. J. (2015). Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology, 232(10), 1793–1801. https://doi.org/10.1007/s00213-014-3810-0


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